Elan: NanoCrystal Technology Publications

1.Merisko-Liversidge, E., McGurk, S., and Liversidge, G.
A Novel Approach for Formulating Poorly Water Soluble Zn-Insulin.Pharmaceutical Research 21 (2004) 1545-1553.2.Cangel, P-C, Bruemel, Y., Seydack, M., Sin,K-K, Wong,L., Merisko-Liversidge, E., Trau, D., and Renneberg, R.,
NanoCrystal Biolabels with Releasable Fluorophores for Immunoassays.Anal. Chemistry 76 (2004) 3638-3645.3.Wu, Y., Loper, A., Landis, E., Hettrick, L., Novak, L., Lynn, K., Chen, C., Thompson, K., Higgins, R., Batra, U., Shelukar, S., Kwei, G. and Storey, D.,
The Role of Biopharmaceutics in the Development of a clinical Nanoparticle Formulation of MK-0869: A Beagle Dog Model Predicts Improved Bioavailability and Diminished Food Effects on Absorption in Humans.Int. J. Pharmaceut. 285 (2004) 135-146.4.Kraft, W., Steiger, B., Beusink, D., Quiring, J., Fitzgerald, N., Greenberg, H. and Waldman, S.
The Pharmacokinetics of Nebulized Nanocrystal Budesonide Suspension in Healthy Volunteers.J. Clin. Pharmacol. 44 (2004) 67-72.5.Merisko-Liversidge, E., Liversidge, G. and Cooper, E.
Nanosizing: a formulation approach for poorly-water-soluble compounds.Eur. J. Pharm. Sci. 18 (2003) 113 120.6.Merisko-Liversidge, E., Liversidge, G. and Cooper, E.
NanoCrystal Drug Particles: Resolving Pharmaceutical Formulation Issues Associated with poorly-Water-Soluble Compounds.Abs. Papers Amer. Chem. Soc. 226 (2003) PMSE 4447.Vergote, G., Vervaet, C., VanDriessche, I., Hoste, S., DeSmedt, S., Demeester, J., Jain, R., Ruddy, S. and Remon, J.
In Vivo Evaluation of Matrix Pellets Containing Nanocrystalline Ketoprofen.Int. J. Pharmaceut. 240 (2002) 79-848.Jain, R., Patel, P. and Ruddy, S.
Development of a Nanoparticulate Suspension-Layered Bead Formulation of a Poorly Water-Soluble DrugAAPS Pharm. Sci. Suppl., 5 (2003) T3038.9.Jain, R., Patel R. and S.B. Ruddy, S.
Development of an Immediate Release and Delayed Release Bead Formulation of a Poorly Water-Soluble Drug.AAPS Pharm. Sci. Suppl., 5 (2003) T3037.10.Pruitt, J., Ryde, T. and Bosch, W.
Increased Absorption of Meloxicam Utilizing NanoCrystal Technology.AAPS Pharm. Sci. Suppl. 5 (2003) R609411.Cooper, E.
Drug Delivery Characteristics of Nanocrystals.Abs. Papers Amer. Chem. Soc. 224 (2002) COLL 239.12.Cunningham, J. and Merisko-Liversidge, E.
Novel Nanoparticulate Formulations of Nystatin for Oral Candidiasis.AAPS Pharm. Sci. Suppl. 4 (2002) R615313.Vergote, G., Vervaet, C., VanDriessche, I., Hoste, S., DeSmedt, S., Demeester, J., Jain, R., Ruddy, S. and Remon, J.
An Oral Controlled Release Matrix Pellet Formulation Containing Nanocrystalline Ketoprofen.Int. J. Pharmaceut. 219 (2001) 81-8714.Donnelly, J., Mouton, J., Blijlevens, N., Smiets, A., Verweij, P and Depauw, B.
Pharmacokinetics of a 14 day Course of Itraconazole Nanocrystals Given Intravenously to Allogenic Haematopoietic Stem Cell Transplant Patients.Antimicrobial Agents Chemotherapy 41 (2001) 5.15.Gottardy, G. and Merisko-Liversidge, E.
Poorly Water Soluble New Chemical Entities: A Nanoparticulate Approach.AAPS Pharm. Sci. Suppl. 3 (2001) M2132.16.Wisner, E., Theon, A., Griffey, S. and McIntire, G.
Long-Term Effect of Irradiation on Lymph Node Uptake of Interstitially Delivered Nanoparticulate Contrast Media.Invest Radiol 35 (2000) 199-20417.Liu, Y., Bacon, E., Ballinger, K., Black, C., Illig, K., McIntire, G., Wang, P., ONeil, N., Kinter, L. and Desai, V.
Pharmacokinetics and Hepatic Disposition of Bis(1-(ethoxycarbonyl)propyl)5-acetylamino-2,4,6-triiodisophthalate in Rats and Isolated Perfused Rat Livers.Drug Met Disposition 28 (2000) 731-736.18.Vergote, G., Vervaet, C., De Smedt, S., Jain, R., Ruddy, S., Demeester, J. and Remon, J.
An Oral Sustained Release Matrix Pellet Formulation for Nanocrystalline Ketoprofen.AAPS Pharm. Sci. Suppl., 2 (2000) 1684.19.Lee, R., McShane, J., Shaw, J. and Wood, R.
Particle Size Reduction. In Liu, R., ed. Water-Insoluble Drug Formation.Buffalo Grove: Inter-Pharm. Press, (2000) pp 455-492.20.Ostrander, K., Bosch, W. and Bondanza, M.
An In-Vitro Assessment of a NanoCrystal Beclomethasone Dipropionate Colloidal Dispersion Via Ultrasonic Nebulization.Eur. J. Pharmacut. Biopharm. 48 (1999) 207-215.21.Na, G., Stevens, J., Yuan, B. and Rajagopalan, N.
Physical Stability of Ethyl Diatrizoate Nanocrystalline Suspension in Steam Sterilization.Pharm. Res. 16 (1999) 569-574.22.Na, G., Yuan, B., Stevens, J., Weekley, B. and Rajagopalan, N.
Cloud Point of Nonionic Surfactants: Modulation with Excipients.Pharm. Res. 16 (1999) 562-568.23.Jain, R., Hontz, R. and Swanson, J.
Controlled Release of NanoCrystal Naproxen from Directly Compressed Matrix Tablet.Proceedings Cont. Release Soc. 26 (1999) 883-884.24.Wisner, E., Theon, A., Katzberg, R., Griffey, S. and McIntire, G.
Lymph Node Uptake of Interstitially Delivered Particulate Contrast Media Before and After Irradiation in Dogs.Acad. Radiol. 6 (1999) 119-125.25.Illig, K., Wolf, G. and Bacon, E.
A Nonsurfactant Wetting Agent for the Preparation of Very Small Nanoparticle Suspensions of an Iodinated Contrast Agent.Pharmaceutical Technol. 23 (1999) 92-10426.McIntire, G., Bacon, E. Toner, J., Cornacoff, j., Losco, P., Illig, K., Nikula, K., Miggenburg, B. and Ketai, L.
Pulmonary Delivery of Nanoparticles of Insoluble, Iodinated CT X-Ray Contrast Agents to Ling Draining Lymph Nodes in Dogs.J. Pharm. Sci. 87 (1998) 1466-1470.27.Merisko-Liversidge, E., Liversidge, G., Wei, L., Steel, V., Cooper, E. and Corbett, T.
The effects of particle size on Nanoparticulate Drug Carriers and Drug Particles of Paclitaxel.AAPS Pharm. Sci. (1998) Abstract 0435.28.Ostrander, K., Bosch, H., Jain, R., Wei, L. and Swanson,
J. Pulmonary Delivery of Spray-dried NanoCrystal Colloidal Dispersions.AAPS Pharm. Sci. (1998) Abstract 1963.29.Polin, L., Valerote, F., White, K., Panchapor, C., Pugh, S., Knight, J., LoRusso, P., Hussain, M., Merisko-Liversidge, E., Peltier, N., Patterson,G., Moore, R., and Corbett, T.
Treatment of Human Prostate Tumors PC-3 and TSU-PR1 with Standard and Investigational Agents in SCID Mice.Investigation New Drugs 15 (1997) 99-108.30.Zheng, J and Bosch, W.
Sterile Filtration of NanoCrystal Drug Formulations.Drug Dev. Ind. Pharm. 23 (1997) 1087-109331.Wiedmann, T., Decastro, L. and Wood, R.
Nebulization of NanoCrystals: Production of a Respirable Solid-in-Liquid-in-Air Colloidal Dispersion.Pharm. Res. 14 (1997) 112-116.32.DeGaravilla, L., Peltier, N., and Merisko-Liversidge, E.,
Controlling the Acute Hemodynamic Effects Associated with IV Administration of Particulate Drug Dispersions in Dogs.Drug Delivery Research 37 (1996) 86-96.33.Merisko-Liversidge, E., Sarpotdar, P., Bruno, J., Shaw, M.J., Hajj, J., Corbett, T., Cooper, E., and Liversidge, G.
Formulation and Antitumor Evaluation of NanoCrystalline Suspensions of Poorly Water Soluble Anticancer Drugs.Pharm. Res. 13 (1996) 272-278.34.VanNoord, T., Wright, D., Muller, K., Engers, D., Liversidge, G. and Kuo, B.
Enhancement of Oral Bioavailability by Nanoparticle Technology and the Disposition Profile of an NK-1 Antagonist in Rats and Dogs.Pharm. Res. 13 (1996) S45735.Illig, K., Mueller, R., Ostrander, K. and Swanson, J.
Use of Microfluidizer Processing for preparation of Pharmaceutical Suspensions.Pharmaceut. Tech. 20 (1996) 78-88.36.Wisner, E., Katzberg, R. and Griffey, S.
Characterization of Normal and Cancerous Lymph Nodes on Indirect Computer Tomography Lymphography Studies After Interstitial Injection of Iodinated Nanoparticles.Acad. Radiol. 3(Suppl. 2) (1996) S257-S260.37.Liversidge, G.G. and Cundy, K.C.,
Particle Size Reduction for Improvement of Oral Bioavailability of Hydrophobic Drugs: Part I Absolute Oral Bioavailability of NanoCrystalline Danazol in Beagle Dogs.Int. J. Pharmaceut. 125 (1995) 91-97.38.Liversidge, G.G. and Conzentino, P.,
Drug Particle Size reduction for Decreasing Gastric Irritancy and Enhancing Absorption of Naproxen in Rats.Int. J. Pharmaceut. 125 (1995) 309-313.39.Merisko-Liversidge, E., Shaw, M., McIntire, G., Sarpotdar, P., Cooper, E. Wolf, G., Corbett, T. and Liversidge, G.
Nanoparticles in Drug Delivery.J. Cell. Biochem. Supp 0(19A) (1995) 16840.Corbett, T., Valeriote, F., LoRusso, P., Polin,L., Panchapor, C., Pugh,S., White,K., Knight,J.,Demchik,L., Jones,J.,Jones,L., Lowichik,N.,Biernat,L., Foster,B., Wozniak,A., Lisow,L., Valdivieso,M.,Baker, L., Leopold, W., Sebolt,J., Bissery, M., Mattes, K., Duzubow, J., Rake, J., Perni, R., Wentland, M., Coughlin, S., Shaw, M.J., Liversidge, G., Liversidge, E., Bruno,J., Sarpotdar,P., Moore R., and Petterson,G.
Tumor Models and the Discovery and Secondary Evaluation of Solid Tumor Active Agents.Intl. J. of Pharmacognosy 33 (1995) 102-122.41.Wisner, E., Katzberg, R., Link, D., Griffey, S., Drake, C., Vessey, A., Johnson, D. and Haley, P.
Indirect Computer Tomography Lymphography Using Iodinated Nanoparticles to detect Cancerous Lymph Nodes in a Cutaneous Melanoma Model.Acad. Radiol. 3 (1995) 40-4842.Wolf, G., Gazelle, G., McIntire, G., Bacon, E., Toner, J., Cooper, E. and Haley, P. Percutaneous Computer Tomography Lymphography in the Rabbit by Subcutaneously Injected Nanoparticles.Acad. Radiol. 1 (1994) 352-357.43.Wisner, E., Katzberg, R., Koblik, P., Shelton, D., Fisher, P., Griffey, S., Drake, C., Harnish, P., Vessey, A., Haley, P., Sarpotdar, P. and Rajagopalan, R.
Iodinated Nanoparticles for Indirect Computer Tomography Lymphography of the Craniocervical and Thoracic Lymph Nodes in Normal Dogs.Acad. Radiol. 1 (1994) 377-38444.Gazelle G., Wolf, G., Bacon, E., McIntire, G., Cooper, E. and Toner, J. Nanocrytalline Computer Tomography Contrast Agents for Blood-Pool and Liver-Spleen Imaging.Investigative Radiol. 29 (1994) S286-S288.45.Rubin, D., Desser, T. Qing, F., Muller, H., Young, S., McIntire, G., Bacon, E., Cooper, E. and Toner, J
Nanoparticulate Contrast Media: Blood-Pool and Liver-Spleen Imaging.Investigative Radiol. 29 (1994) S280-S283.46.Wolf, G., Gazelle, S., McIntire, G., Bacon, E., Toner, J. and Cooper, E.
Percutaneous Computer Tomographic Lymphography of Normal, Inflamed, and Cancerous Nodes in the Rabbit.Investigative Radiol. 29 (1994) S30-S32.47.Wolf, G., Gazelle, G., McIntire, G., Bacon, E., Cooper, E. and Toner, J.
Percutaneous Lymphography of Normal, Inflamed and Cancerous Nodes.Radiology 189(P) (1993) 29648.Peltier, N, Steel, V., Uhl, J., Brophy, L. and Merisko-Liversidge, E.
Direct Suppression of Phagocytosis by Amphipathic Surfactants.Pharm. Res. 9 (1992) 1177-1183.

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